ABSTRACT
Introduction : Non-alcoholic Fatty Liver Disease (NAFLD), a hepatic manifestation of Metabolic Syndrome, has now become a Global Phenomenon and along with its increasing prevalence various morbidities and mortality are also increasing. Aims and Objectives : The objective of the present study was to establish whether patients with NAFLD, in the absence of other comorbid conditions suffer from cognitive impairment. Materials and Methods : This cross sectional study was conducted at the Department of General Medicine, Calcutta National Medical College and Hospital. 90 patients with NAFLD and 90 healthy controls were recruited after matching all the inclusion and exclusion criteria, from the out patient and in patient department over a period of 1 year starting March, 2019. NAFLD was diagnosed by noninvasive methods including Elastography (fibroscan). Cognition was assessed by MoCA (Montreal Cognitive Assessment test) score. Result : The mean age of cases and control were 49.2 and 48.5 years, respectively. Out of total cases and controls 48.9% was male and 51.1% was female. The mean BMI of the cases and control were 30.21�24 and 22.60�52 Kg/m2, respectively. The mean Elastography score among the cases was 4.91�23 kPa and that among the controls was 3.84�31 kPa. The mean Fibroscan Score among male cases and controls were 4.907�26 kPa and 3.83�35, respectively (p
ABSTRACT
Background: Type 2 diabetes mellitus patients frequently have various distressing gastrointestinal signs and symptoms and intestinal alkaline phosphatase (IAP) may be linked to it. Even after extensive search, there was dearth of literature related to IAP levels in serum of diabetic enteropathy subjects. So, using a case-control design, levels of IAP in the serum of T2DM subjects were determined.Methods: Serum IAP was measured by ELISA in 73 type 2 diabetic patients with enteropathy (group 1) and 71 type 2 diabetic patients without enteropathy (group 2). Statistical analysis of the data was performed by using Statistical Package for Social Sciences (SPSS version 16) and inferences were drawn.Results: Serum IAP was highly significantly reduced in group 1 (3.9 U/L) compared to group 2 (4.2 U/L).Conclusions: Enteropathy in T2DM may be related to reduction in IAP levels in serum. Estimation of serum IAP may be considered in type 2 diabetic patients with enteropathy, for the elaboration of treatment strategy and monitoring.